RuDaCoP: The Dataset for Smartphone-based Intellectual Pedestrian Navigation

This paper presents the large and diverse dataset for development of smartphone-based pedestrian navigation algorithms. This dataset consists of about 1200 sets of inertial measurements from sensors of several smartphones. The measurements are collected while walking through different trajectories up to 10 minutes long. The data are accompanied by the high accuracy ground truth collected with two foot-mounted inertial measurement units and post-processed by the presented algorithms. The dataset suits both for training of intellectual pedestrian navigation algorithms based on learning techniques and for development of pedestrian navigation algorithms based on classical approaches. The dataset is accessible at http://gartseev.ru/projects/ipin2019

Vascular Endothelial Growth Factor in Anterior Chamber Liquid Patients with Diabetic Retinopathy, Cataract and Neovascular Glaucoma

INTRODUCTION: The aims of this study were: (1) to investigate the association of vascular endothelial growth factor isoform A (VEGF-A) concentration in the anterior chamber liquid (ACL) with vascular proliferation in patients with diabetic retinopathy (DR) who had undergone surgical treatment for cataract and neovascular glaucoma; (2) to analyze the association of VEGF-A level in ACL with the cataract surgery outcomes. MATERIALS AND METHODS: Undiluted aqueous fluid samples were obtained from 207 eyes of patients who underwent intraocular surgery, 136 patients with diabetes mellitus (DM) and 22 patients without DM. The ACL samples were obtained during operation. The VEGF-A levels were analyzed by enzyme-linked immunosorbent assay. RESULTS: The lowest VEGF-A levels were in diabetic patients without signs of DR [22.75 pg/mL (10.78; 63.36)]. More severe DR tended to occur in diabetic patients with higher VEGF-A levels in ACL. In diabetic patients with proliferative DR (PDR), VEGF-A levels were significantly higher [336.6 pg/mL (232.3; 410.74)] than in patients without DR P < 0.0001. In patients with terminal stage of DR [neovascular glaucoma (NG)], VEGF-A levels were dramatically higher and attained 1,634.01 pg/mL (610.69; 2657.33). In non-diabetic patients, VEGF-A levels were 95.07 pg/ml (60.92; 129.22). The best visual acuity results in post-operative period were observed in the group of diabetic patients without DR. In the group of patients with PDR, post-operative visual acuity [0.26 (0.1; 0.42)] was similar to visual acuity before operation [0.29 (0.13; 0.44)]. There was no significant increase in visual acuity due to cataract surgery. In 52.4% patients, no complications had occurred by the end of the follow-up period. In 40% patients, retinal laser coagulation was performed, and in 7.6% patients NG had developed. CONCLUSION: VEGF-A level in ACL increases with DR progression and may be of prognostic value in evaluating the potential risk of further neovascularization progression in diabetic patients

Epoxy Compositions with Reduced Flammability Based on DER-354 Resin and a Curing Agent Containing Aminophosphazenes Synthesized in Bulk Isophoronediamine

A method for the synthesis of an amine-containing epoxy resin curing agent by dissolving hexakis-[(4-formyl)phenoxy]cyclotriphosphazene in an excess of isophoronediamine was developed. The curing agent was characterized via NMR and IR spectroscopy and MALDI-TOF mass spectrometry, and its rheological characteristics were studied. Compositions based on DER-354 epoxy resin and the synthesized curing agent with different amounts of phosphazene content were obtained. The rheological characteristics of these compositions were studied, followed by their curing. An improvement in several thermal (DSC), mechanical (compression, tension, and adhesion), and physicochemical (water absorption and water solubility) characteristics, as well as the fire resistance of the obtained materials modified with phosphazene, was observed, compared with unmodified samples. In particular, there was an improvement in adhesive characteristics and fire resistance. Thus, compositions based on a curing agent containing a 30% modifier were shown to fulfill the V-1 fire resistance category. The developed compositions can be processed by contact molding, winding, and resin transfer molding (RTM), and the resulting material is suitable for use in aircraft, automotive products, design applications, and home repairs

QCL active region overheat in pulsed mode: effects of non-equilibrium heat dissipation on laser performance

Quantum cascade lasers are of high interest in the scientific community due to unique applications utilizing the emission in mid-IR range. The possible designs of QCL are quite limited and require careful engineering to overcome some crucial disadvantages. One of them is an active region (ARn) overheat, that significantly affects the laser characteristics in the pulsed operation mode. In this work we consider the effects related to the non-equilibrium temperature distribution, when thermal resistance formalism is irrelevant. We employ the heat equation and discuss the possible limitations and structural features stemming from the chemical composition of the AR. We show that the presence of alloys in the ARn structure fundamentally limits the heat dissipation in pulsed and CW regimes due to their low thermal conductivity. Also the QCL post-growths affects the thermal properties of a device only in (near)CW mode while it is absolutely invaluable in the pulsed mod

Trends in the epidemiology of diabetic retinopathy in Russian Federation according to the Federal Diabetes Register (2013–2016)

Background: Diabetic retinopathy (DR) is one of the most common causes of blindness in patients with diabetes mellitus (DM) that is why its necessary to study the epidemiological characteristics of this complication. Aims: The aim of the study was to evaluate the epidemiological characteristics of DR and blindness in adult patients with type 1 (T1) and 2 (T2) diabetes in Russian Federation (RF) for period 201316years. Materials and methods: Database of Federal Diabetes register, 81st regions included in the online register. Indicators were estimated per 10,000 adult DM patients (18years). Results: In 2016 the DR prevalence in RF was T1 38,3%, T2 15,0%, with marked interregional differences: 2,666,1%, 1,146,4%, respectively. The DR prevalence within 20132016 years was: T1 3830,93805,6; T2 1586,01497,0. Trend of new DR cases/per year increased: T1 153,2187,8; T2 99,7114,9. The structure of new cases of DR in 2016: non-proliferative stage (T1 71,4%, T2 80,3%), pre-proliferative stage 16,4%, 13,8%, proliferative 12,1%, 5,8%, terminal 0,2%, 0,1%, respectively, these data indicated the earlier detection of DR. The mean age of DR diagnosis increased: T1 by 1,2 years, T2 by 2,6. The average DM duration of DR determine increased T1 9,613,1 years, T2 6,09,1. The prevalence of blindness tends to decrease: T1 92,390,8; T2 15,415,2/10.000 DM adults. The amount of new cases of blindness/per year increased: T1 4,34,6; T2 1,21,4. The mean age of blindness increased: T1 39,141,6 years, T2 64,467,4; the mean duration of diabetes before blindness occur (from the time of DM diagnosis) increased: T1 20,221,2 years, in T2 10,711,3. We observed growth of DR treatment (laser surgery, vitrectomy, anti-VEGF medication) but the frequency of use in T2 patients is about 2 times less than in T1. Conclusions: There was a decrease in the overall incidence of eye damage in diabetes (DR and blindness) in the analyzed period in RF. DR and blindness develops at advanced age and with a longer duration of diabetes. As the main directions of eye care development in diabetes it is necessary to standardize primary care in the regions, to unify the examination algorithms and methods of early diagnostic, to increase the continuity and interaction of endocrinologists and ophthalmologists in managing patients with diabetes in order to prevent the development of new cases of vision loss

Lokus geneticheskoy predraspolozhennosti k diabetu I tipa

Инсулинзависимый сахарный диабет (ИЗСД) является мультифакторным заболеванием, характеризующимся специфическим аутоиммунным разрушением бета-клеток Лангерганса поджелудочной железы. Предрасположенность к ИЗСД обусловлена как генетическими факторами, так и условиями окружающей среды. Сканирование генома человека выявило 12 локусов предрасположенности к ИЗСД на разных хромосомах. Локусы предрасположенности к ИЗСД были сначала определены как гаплотипы DR3 и DR4 серологическими методами. Полиморфизм генов главного комплекса гисто?совместимости класса III также может быть связан с предрасположенностью к диабету 1 типа. Эти гены кодируют компоненты С2 и С4 комплемента и пропердиновый фактор В. Выдвинуто предположение о том, что область генов главного комлекса гистосовместимости между локусами ВАЛ и HLA-B содержит гены, играющие важную роль в развитии ИЗСД. Гены HLA вовлечены не только в развитие диабета 1 типа. Отмечена их связь с инсулиннезависимым (ИНСД) диабетом. В популяциях европеоидов с максимальным риском ИНСД связаны лишь молекулярные варианты DQ а-цепей Арг52+/Арг52 +, в отличие от ИЗСД, в предрасположенность к которому важный вклад вносят и продукты гена DQB1. Генетические исследования свидетельствуют о наличии HLA-детерминант, общих для обоих типов диабета

LOKUSY GENETIChESKOY PREDRASPOLOZhENNOSTI K DIABETU 1 TIPA IDDM3, IDDM4 I IDDM5 (SOOBShchENIE 3)

Локусы предрасположенности к сахарному диабету I типа (СД 1) IDDM3, IDDM4 и IDDM5 не вносят значительного вклада в семейную кластеризацию заболевания. Локус IDDM3 был впервые картирован в 1994 г. на хромосоме 15q26. Конкретные гены, которые могут быть сцеплены с СД, пока не отождествлены с локусом 1DDM3. Локус IDDM4. Выдвинув гипотезу о полигенном характере СД 1, исследователи указали на вовлеченность в развитие патологии по меньшей мере трех генов, один из которых был ассоциирован с генами главного комплекса гистосовместимости на мышиной хромосоме 17, а другой находился проксимальнее генного кластера Thy-1 /Alb-1, расположенного на хромосоме 9. В геноме человека данному класте?ру соответствуют гены THY1 и АРОА1, локализованные на хромосоме llq. Локус IDDM5. Широкомасштабное геномное сканирование выявило на хромосомном плече 6q 2 соседствующих друг с другом локуса предрасположенности, названные IDDM5 и IDDM8. 1-й расположен в области 6q24-q25, а 2-й - на участке 6q25- q27. Другое исследование по картированию 1DDM5 с использованием 7 маркеров и охватом района хро?мосомы размером до 15 сМ показало достоверность возрастания частоты передачи "диабетогенных" аллелей от больных родителей детям лишь у маркера в гене ESR (MLS=0,9). По оценке Луо и соавт., размер области предрасположенности 1DDM5 равен примерно 5 сМ. Требуется провести более детальное изучение данного участка хромосомы на предмет поиска конкретных генов, обнаруживающих связь с развитием СД

Binders Used for the Manufacturing of Composite Materials by Liquid Composite Molding

Binders, or tackifiers, have become widespread in the production of new composite materials by liquid composite molding (LCM) techniques due to their ability to stabilize preforms during laying-up and impregnation, as well as to improve fracture toughness of the obtained composites, which is very important in aviation, automotive, ship manufacturing, etc. Furthermore, they can be used in modern methods of automatic laying of dry fibers into preforms, which significantly reduces the labor cost of the manufacturing process. In this article, we review the existing research from the 1960s of the 20th century to the present days in the field of creation and properties of binders used to bond various layers of preforms in the manufacturing of composite materials by LCM methods to summarize and synthesize knowledge on these issues. Different binders based on epoxy, polyester, and a number of other resins compatible with the corresponding polymer matrices are considered in the article. The influence of binders on the preforming process, various properties of obtained preforms, including compaction, stability, and permeability, as well as the main characteristics of composite materials obtained by various LCM methods and the advantages and disadvantages of this technology have been also highlighted

Lokus geneticheskoy predraspolozhennosti k diabetu 1 tipa IDDM2 (Soobshchenie 2)

Главный вклад в генетический компонент развития ИЗСД вносит локус IDDM1, определяющий, насколько риск развития заболевания у потомков больных ИЗСД превышает величину среднего риска для популяции. IDDM2 - другой генетически детерминированный локус предрасположенности. Локус предрасположенности 1DDM2 расположен в гене (INS) на хромосоме 11р15.5. Вскрытие механизмов взаимодействия между разными генетическими локусами предрасположенности к одному и тому же наследственному заболеванию является важной ступенью в раскрытии их роли в патогенезе последнего. Так, локусы IDDM1 и IDDM2 могут взаимодействовать друг с другом через посредство продуктов экспрессии, участвующих в одних и тех же или перекрывающихся биохимических путях, нарушение которых приводит к развитию диабета

COMMUNICATION OF EDUCATIONAL ATTAINMENT AND INCOMES: THE REASONS AND DISCREPANCY CONSEQUENCES

According to the theory of human capital improvement of education attainment results in increase of income of human capital’s owner. This issue is interest to majority of wage earners, all the more at the economic crisis. Authors of this paper analyze presence and closeness of connection between worker’s education attainment and amount of salary on data of Kaluga region. In the paper probable reasons and discrepancy of revealed issue